Total Synthesis of Human Galanin-Like Peptide through an Aspartic Acid Ligation
Xiaoyang Guan , Matthew R. Drake , Zhongping Tan,  Org. Lett., 2013, Article ASAP
DOI: 10.1021/ol402984r
Publication Date (Web): November 22, 2013
Copyright © 2013 American Chemical Society

Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of hGALP. The total synthesis of hGALP enhances our ability to study its biology and facilitates the development of more stable analogues.